Wishart Node of The Metabolomics Innovation Centre

Equipment

The Wishart Node of TMIC has a full suite of state-of-the-art equipment for metabolmic analysis. Contact us for suggestions on which piece of equipment and what type of analysis is best suited for your project.  Mouse over each piece of equipment for the name and a brief description.  For a more detailed description of the equipment, click here.

AB Sciex QTRAP 4000 MS

AB Sciex QTRAP 4000

Tandem quadrupole and ion trap instruments are ideal for targeted and quantitative studies. Multiple reaction monitoring (MRM) is used on these instruments to selectively measure specific metabolites and their internal standard, providing absolute quantitation.

Agilent 1290 Infinity II UHPLC

Agilent 1290 Infinity II UHPLC

High Performance Liquid Chromatography is one of the most powerful and versatile analytical techniques for separation, identification, and quantification of metabolites present in different biofluids and plant materials. Detectors coupled to HPLC used in our laboratory are UV, Fluorescence, and Evaporative Light Scattering Detector (ELSD).

Bruker Maxis QTOF MS

Bruker MaXis QTOF MS

Liquid chromatography-mass spectrometry, or LC-MS instrumentation is capable of tandem quadrupole, ion trap, analysis for both targeted and untargeted studies. It is a powerful chemical identification technique that combines physical separation via liquid chromatography (HPLC) with mass spectrometry for mass analysis. The high sensitivity and selectivity of LC-MS mean it is generally used to detect and identify particular chemicals in a chemical mixture, though it can also be used for purification purposes. LC-MS is commonly used in pharmacokinetic studies, drug development, and metabolite profiling.

Parker Nitrogen Generator

Parker Nitrogen Generator

Nitrogen gas generators produce high purity nitrogen from compressed air. Housing the generator in the Wishart Node Lab eliminates the need to rely on outside companies to deliver nitrogen.

Perkin-Elmer NexION ICP-MS

ICP-MS

ICP-MS is used for quantitative metallomics. We routinely identify and quantify 20-40 metal ions in a wide variety of biological matrices.

AB Sciex QTRAP 5500 MS

AB Sciex QTRAP 5500

Tandem quadrupole and ion trap instruments are ideal for targeted and quantitative studies. Multiple reaction monitoring (MRM) is used on these instruments to selectively measure specific metabolites and their internal standard, providing absolute quantitation.

AGILENT-7890A-GC-MS-1

AGILENT-7890A-GC-MS-1

Gas Chromatography - Mass Spectrometry is a very powerful technique and has been regarded as the gold standard for analyzing lipids, drug metabolites and environmental analysis for many years. One of the advantages of GC-MS is that the identification is based on both a retention time and a mass spectrum (a compounds' specific fragmentation pattern).

NMR 700MHZ Bruker Cold Probe

NMR 700MHZ Bruker Cold Probe

Nuclear Magnetic Resonance is a powerful spectroscopic technique that measures the absorption of radio-frequency radiation by different nuclei (within a chemical compound) when that compound is placed under a strong magnetic field. It gives information about both the structural and chemical properties of certain molecules. NMR is unique as it is one of the few non-destructive methods for analyzing 3D structure and molecular dynamics.

Thermo QExactive HF with Vanquish UHPLC

Thermo QExactive HF with Vanquish UHPLC

Ultra-high performance liquid chromatography systems feature a design focused on uptime, robustness and reliability. Multiple detection options make performance and flexibility possible. These systems are ideal for method development or high-throughput analyses.

Thermo TSQ Altis H Binary UHPLC

Thermo TSQ Altis H Binary UHPLC

This piece of equipment features analytical precision, including unsurpassed peak area and retention time precision.