LC-MS Targeted (1-Carbon Metabolism)


LC-MS Targeted (1-Carbon metabolism) metabolomic analysis is useful for plasma, serum, urine, tissues, saliva, milk, cell media, cell lysate, cells


Matrices / Biosamples:  Plasma, Serum, Urine, Tissues, Saliva, Milk, Cell Media, Cell Lysate, Cells

Volume Requirement:  20 ul; 30 mg

Pathways: 1-Carbon metabolism

Compound Classes:  Amino acids, vitamins, co-factors, lipid precursors

Cost per Sample:  Academic/Government $40; Industry $55

Number of Compounds:  10

Quantitative:  Absolute

Compound List:  Betaine, Folate, Homocysteine, L-Methionine, L-Serine, S-adenosylmethionine, Tetrahydrofolate, Vitamin B12, Glutamate, Glycine

Species: Humans, Mice, Rats, Livestock

Validation or Publication:  PMID: 30706502; Minerbi, A.; Gonzalez, E.; Brereton, N. J. B.; Anjarkouchian, A.; Dewar, K.; Fitzcharles, M. A.; Chevalier, S.; Shir, Y. Altered microbiome composition in individuals with fibromyalgia. Pain 2019, 160, 2589-2602. Anal. Chem. 2020, 92, 15, 10627–10634;
Magan, J. B.; O’Callaghan, T. F.; Zheng, J.; Zhang, L.; Mandal, R.; Hennessy, D.; Fenelon, M. A.; Wishart, D. S.; Kelly, A. L.; McCarthy, N. A. Impact of bovine diet on metabolomic profile of skim milk and whey protein ingredients. Metabolites 2019, 9, 10.3390/metabo9120305. Metabolites 2020, 10, 233; doi:10.3390/metabo10060233

Additional information

Client Classification

Industry, Government, Academic